FDSS7000EX Functional Drug Screening System
The FDSS7000EX is our high-end model capable of handling 1536-well assays and measuring both fluorescence and luminescence, and is equipped with a variety of functions such as multiple washing. Many kinds of suspended/adherent cells' real-time kinetic reactions can be measured and analyzed. Various optional parts such as FRET, robot connections, etc. are available. In addition, the FDSS7000EX is expandable for future upgrades.
Special sites
This site features drug discovery solutions. We provide various information about drug discovery solutions from this site, for example, our high performance drug screening systems, workshop information, related documents, and so on.
Applications
- Intracellular calcium ion
- Membrane potential
- Ion channel
- Aequorin
- FRET
- Suspended cell
◇Measurement example: Intracellular calcium ion
Comparison of calcium mobilities using Aequorin, Fluo-3, and Fura-2 receptor-expressing cells.
Hardware
Dispenser
Can be equipped with various dispenser heads
- 96-, 384-, or 1536-tip dispenser heads are selectable. The tips are exchangeable.
- 384- and 1536-pintool heads are also supported.
- The main unit is equipped with an automatic tip loading feature.
- As standard, three types of compounds can be dispensed. If you use the back plate loading line, up to four types of compounds can be dispensed.
- The dispenser heads can be easily changed by the user.
Washing unit
Equipped with a variety of washing features
- Up to three solvents are supported, which enables washing with no carry over.
- Tips can be washed during measurement.
- An ultrasound washing feature is also available.
- Equipped with a wiping stage to dry tip ends.
Plate stacker unit
Plate stacker feature for 20 or 50 plates
- Using the plate stacker makes it possible to perform automatic measurements even without the use of a robot.
- You can select 20 plates or 50 plates.
- Stacker cassette method makes it easy to set plates.
- Can be equipped with a barcode reader.
Plate shaking features
Plate shaking provides stable response detection.
- Measurements can be performed while applying fine vibrations to the whole plate.
- Cells and reagents can be mixed effectively and quickly.
- This is also effective for assays that use suspended cells.
Fluorescence/luminescence sensor, Fluorescence optics
Supports fluorescence assays and luminescence assays with a single sensor
- This sensor has a fluorescence detection sensitivity that far exceeds that of conventional fluorescence sensors.
- Because the excitation light can be lowered, the cost of purchasing excitation light sources can be reduced.
- In addition to high sensitivity, the FDSS7000EX also has a high dynamic range.
- The fluorescence changer makes FRET measurements possible.
Various assays with xenon lamp & filter combination (multiple excitation and emission)
- Good wavelength separation by epi-illumination optics
- Fura-2 assay with dual excitation (340 nm & 380 nm)
- FRET (C/Y, Membrane potential) with emission filter changer
- 2 dichroic mirror and 4 emission filter slots for various assays
- White light xenon lamp with wattage options (150 W, 300 W, 600 W)
- 6 filter slots for excitation
- Uniform plate illumination
Specifications
| Type number | FDSS7000EX |
|---|---|
| Main unit dimensions | Approx. 1500 mm (W)×1030 mm (D)×1450 mm (H) |
| Main unit | Up to approx. 300 kg |
| Data analysis system dimensions | 600 mm (W)×700 mm (D)×1500 mm (H) |
| Data analysis system weight | Approx. 50 kg |
| Pump unit/Tank dimensions | 500 mm (W)×500 mm (D)×1200 mm (H) |
| Pump unit/Tank weight | Approx. 50 kg |
Related information
- FDSS Option 2: High Speed Acquisition Option [0.2 MB/PDF]
- FDSS Option 1: 1536-Well Format Option with Disposable Tips and Pin Tool Head [0.2 MB/PDF]
- FDSS Application Note No.27 Kinetic Luminescent Measurement of ROS (Reactive Oxygen Species) production with ABEL Cell activation ROS kit with PHOLASIN on the FDSS/μCELL platform [0.2 MB/PDF]
- FDSS Application Note No.26 BRET2 assay using the FDSS/μCELL: monitoring cell surface-receptor internalization [0.1 MB/PDF]
- FDSS Application Note No.25 Identification of small molecule modulators of reactive oxygen release in TNF-α primed primary human neutrophils. [0.1 MB/PDF]
- FDSS Application Note No.24 Evaluation of membrane potential assay kit using the FDSS/μCELL imaging plate reader: Detection ion channel in nicotinic acetylcholine receptors (nAChRs) [0.1 MB/PDF]
- FDSS Application Note No.23 BRET1-assay using the FDSS/μCELL imaging plate reader [0.1 MB/PDF]
- FDSS Application Note No.22 High Speed Data Acquisition Option for FDSS series [0.4 MB/PDF]
- FDSS Application Note No.21 Cell-based fluorescent assay for selectivity evaluation between two Na+ channels subtypes [0.2 MB/PDF]
- FDSS Application Note No.20 New Tools for Drug Discovery: Multiplexing the monitoring of Ca2+ and cAMP signaling in primary cells using the FDSS/μCell. [0.4 MB/PDF]
- FDSS Application Note No.19 Fast kinetics enzyme assay High-throughput screening of prolyl isomerase inhibitors [0.1 MB/PDF]
- FDSS Application Note No.18 β-arrestin recruitment for GPCR Screening [0.1 MB/PDF]
- FDSS Application Note No.17 Use of Ca2+ oscillations in primary neuron culture: a new HTS model for neuronal diseases [0.3 MB/PDF]
- FDSS Application Note No.16 FluxORTM Differentially Identifies K+ Channel Antagonists Using FDSS6000 [0.1 MB/PDF]
- FDSS Application Note No.15 Exposing cells to a single pulse of light of user-defined wavelength and duration using the FDSS6000 [0.1 MB/PDF]
- FDSS Application Note No.14 Evaluation of a new intracellular calcium fluorescent reagent using the FDSS6000 [0.4 MB/PDF]
- FDSS Application Note No.13 Incorporating Cell Viability Assays into High Throughput Screening Using the FDSS6000 [0.1 MB/PDF]
- FDSS Application Note No.12 Fluorescence Quenching in Cell-Based Assays Can Be Dye Specific: A Case Study Using Both Fura-2 AM and Fluo-4 AM Calcium Reporter Dyes Using the FDSS6000 [0.1 MB/PDF]
- FDSS Application Note No.11 Detection and Modulation of Cardiomyocyte Calcium Oscillations Using the FDSS6000 [0.1 MB/PDF]
- FDSS Application Note No.10 Comparison of Orthogonal Technologies to Confirm Agonist Hits Generated Using the FDSS6000 [0.1 MB/PDF]
- FDSS Application Note No.9 Effect of Plate Mixing, Fluid Addition Height and Speed on Reducing Addition Artifacts and Negative Control Drift Using the FDSS6000 [0.1 MB/PDF]
- FDSS Application Note No.8 Comparison of No Wash Reagent Kits on the FDSS6000 [0.4 MB/PDF]
- FDSS Application Note No.7 Multiplexing Calcium Mobilization and Membrane Potential Assays Using the FDSS6000 [0.3 MB/PDF]
- FDSS Application Note No.6 Direct comparison of Fast response and Slow response Membrane potential dye using the FDSS6000 [0.1 MB/PDF]
- FDSS Application Note No.5 COX flash luminescence screening [0.1 MB/PDF]
- FDSS Application Note No.4 FDSS Cell dispensing unit for Aequorin Flash luminescence [0.4 MB/PDF]
- FDSS Application Note No.3 FRET-based Voltage Sensor dyes for Drug Screening [0.1 MB/PDF]
- FDSS Application Note No.2 CoroNa Red as a potential probe for intracellular sodium imaging [0.1 MB/PDF]
- FDSS Application Note No.1 Chloride ion sensitive fluorescent dye for Drug Screening [0.1 MB/PDF]
